The Bipolar Network News site (www.bipolarnews.org) has recently reported on an important study carried out on twins and one reason behind their differential susceptibility to developing bipolar disorder. The article, entitled: ‘Twin Study Helps Clarify Epigenetic Component to Bipolar Disorder’ reports on some very interesting findings.
The Bipolar Network News site reported that, at the 2014 meeting of the International Society for Bipolar Disorders, a team led by J. Ayers Ringlera presented the finding of their twins study. What they found was that ill twins showed more methylation of the gene for amino acid transporter 2 (EAAT2) – this clears the excitatory neurotransmitter glutamate from the synapse of neurons. And why is this important? Well, methylation of the gene suppresses the amount of transporter expressed, so less glutamate gets cleared as a result.
The Ayers Ringlera study adds another piece to the biochemical and genetic jigsaw that is being put together in labs across the world and may shed light on future drug pathways and enhancing current treatments.
You can read the entire article here: http://bipolarnews.org/?p=2620